Testing conditional independence is fundamental yet intrinsically difficult: without additional assumptions, Type I error control is impossible in general. The "Model-X'' paradigm addresses this difficulty by assuming exact knowledge of a relevant conditional distribution. While small deviations from this assumption can sometimes be tolerated in classical one-shot testing, existing sequential conditional independence tests typically require the Model-X conditional to be known exactly, making them fragile when it must instead be estimated. We propose a new approach that is substantially more robust to such estimation error. Our method applies testing-by-betting to an adaptively optimized Kernel Conditional Independence statistic, together with a normalization scheme and a truncate-and-shift calibration strategy. These modifications greatly reduce Type I error inflation while preserving high power across high-dimensional synthetic benchmarks and real-world fairness tasks, outperforming existing sequential Model-X approaches. Code is available at https://github.com/he-zh/SKCI.

Estimating the distribution of outcomes under counterfactual policies is critical for decision-making in domains such as recommendation, advertising, and healthcare. We propose and analyze a novel framework--Counterfactual Policy Mean Embedding (CPME)--that represents the entire counterfactual outcome distribution in a reproducing kernel Hilbert space (RKHS), enabling flexible and nonparametric distributional off-policy evaluation. We introduce both a plug-in estimator and a doubly robust estimator; the latter enjoys improved convergence rates by correcting for bias in both the outcome embedding and propensity models. Building on this, we develop a doubly robust kernel test statistic for hypothesis testing, which achieves asymptotic normality and thus enables computationally efficient testing and straightforward construction of confidence intervals. Our framework also supports sampling from the counterfactual distribution. Numerical simulations illustrate the practical benefits of CPME over existing methods.

Many problems in computational science and engineering become one-to-many after coarse graining, partial observation, or inverse reconstruction: a resolved state may not determine a unique subgrid forcing, a structural descriptor may not determine a unique effective response, and a low-resolution observation may correspond to many plausible high-resolution fields. In such settings, deterministic surrogates may learn a well-defined mathematical object while still missing application-relevant uncertainty. This tutorial develops a self-contained module centered on the conditional-mean barrier: the point at which a squared-loss predictor has reached the conditional mean and the remaining error is irreducible aleatoric variance. We give two diagnostics for locating this barrier, residual-feature orthogonality and the coefficient of determination against its explained-variance ceiling, and prove that adding latent randomness to a squared-loss predictor collapses it back to the conditional mean. Crossing the barrier therefore requires a loss that scores distributions rather than point predictions. We briefly organize common distributional objectives, including negative log-likelihood, moment and observable matching, variational objectives, adversarial divergences, and score matching, by the feature of the conditional law each targets. The emphasis is the boundary itself and a finite-data procedure for recognizing it, rather than a survey of methods beyond it. CPU-based demonstrations on a two-branch law and a two-scale Lorenz-96 closure problem show how the diagnostics distinguish deterministic underfitting from residual distributional variability.

Comparing conditional distributions is a fundamental challenge in statistics and machine learning, with applications across a wide range of domains. While proposed methods for measuring discrepancies using kernel embeddings of distributions in a reproducing kernel Hilbert space (RKHS) provide powerful non-parametric techniques, the existing literature remains fragmented and lacks a unified theoretical treatment. This paper addresses this gap by establishing a coherent framework for studying kernel-based methods to measure divergence between conditional distributions through what we refer to as conditional maximum mean discrepancy (CMMD). The CMMD consists of a family of metrics which we call levels, with three special cases each using a different type of RKHS embedding: CMMD$_0$ (conditional mean operators), CMMD$_1$ (conditional mean embeddings), and CMMD$_2$ (joint mean embeddings). We additionally introduce a general level $s$ CMMD, clarifying the required assumptions, and establishing mathematical connections between the levels through the lens of operator-based smoothing. In addition to reviewing previously proposed estimators, we introduce a novel doubly robust estimator for the CMMD that maintains consistency provided at least one of the underlying models is correctly specified. We provide numerical experiments demonstrating that the CMMD effectively captures complex conditional dependencies for statistical testing.

We can see that the error for the first term is mainly due to the sample approximation. We therefore refer to the first term as the Variance. We refer to the second term as the Bias. Our proof of convergence of the bias adapts the proof in [31, Theorem 6] and [11], and utilizes the fact that CY|X is Hilbert-Schmidt to obtain a sharp rate. A.1 Bounding the Bias In this section, we establish the bound on the bias.

We address the consistency of a kernel ridge regression estimate of the conditional mean embedding (CME), which is an embedding of the conditional distribution of Y given X into a target reproducing kernel Hilbert space HY . The CME allows us to take conditional expectations of target RKHS functions, and has been employed in nonparametric causal and Bayesian inference. We address the misspecified setting, where the target CME is in the space of Hilbert-Schmidt operators acting from an input interpolation space between HX and L2, to HY . This space of operators is shown to be isomorphic to a newly defined vector-valued interpolation space. Using this isomorphism, we derive a novel and adaptive statistical learning rate for the empirical CME estimator under the misspecified setting. Our analysis reveals that our rates match the optimal O(logn/n) rates without assuming HY to be finite dimensional. We further establish a lower bound on the learning rate, which shows that the obtained upper bound is optimal.

We present a novel approach for explaining Gaussian processes (GPs) that can utilize the full analytical covariance structure present in GPs.

The asymptotic behavior of the proposed estimation procedure is studied. Our theoretical results show that the proposed method can achieve a faster convergence rate than the optimal convergence rate for sampling methods.